Ultimate U.S. Cross-Country Road Trip Routes

Dreaming of hitting the open road, discovering hidden gems, and soaking in some of the most breathtaking landscapes in the United States? Whether you’re an adventure seeker, a family ready to bond over long drives, or an international traveler eager to explore the heart of America, these epic road trip routes are perfect for you. 

Each trip offers unforgettable sights, experiences, and memories that will last a lifetime—all in just one to two weeks. As you travel across the country, an eSIM USA plan will ensure you can stay connected no matter what states you cross through on your journey. 

Here are five carefully curated road trip routes that showcase the very best of the U.S. landscapes, attractions, and local charm. 

1. Pacific Coast Highway – California 

The Pacific Coast Highway (PCH) is not just a route; it’s an experience. Running along California’s stunning coastline, this road trip is a dream for ocean lovers and outdoor enthusiasts alike. 

Start your roadtrip in Rockport, California and drive south along the coast. Enjoy stopping by a plethora of beaches and parks, as well as driving through quintessential Californian coastal towns. End your trip in Dana Point, California with a dolphin or whale watching cruise. 

Must-See Highlights: 

• Fort Bragg: Stop by MacKerricher State Park, particularly at the Glass Beach with its shore of colorful glass stones. 
• Bixby Bridge: An iconic photo stop offering jaw-dropping views of the rugged coastline and the vast Pacific Ocean. 
• Golden Gate Bridge: Drive over this iconic bridge and past Golden Gate Park as you continue to make your way south. 
• Big Sur: Lose yourself in the dramatic cliffs, forested trails, and serene beaches of this magical coastal stretch. 
• Monterey Bay Aquarium: A perfect pit stop for families, featuring mesmerizing marine exhibits and insights into the underwater world. 

Why You’ll Love It: The Pacific Coast Highway offers unparalleled scenery, with every twist and turn unfolding a new postcard-worthy view. Keep your camera ready—you'll be snapping endlessly under the Californian sun. 

2. Route 66 – From Chicago to Los Angeles 

Known as the “Mother Road,” Route 66 is a quintessential American road trip packed with nostalgia, quirky stops, and awe-inspiring landscapes. 

Begin your journey in the Windy City – Chicago, Illinois. As you drive south and west, make your way throught the Land of Lincoln (Illinois) before passing through six more states to reach Santa Monica, California (outside of Los Angeles). 

Must-See Highlights: 

• Grand Canyon: Take a detour from Flagstaff to marvel at one of the natural wonders of the world. 
• Petrified Forest National Park: Explore the unique landscape of fossilized trees and vibrant desert colors. 
• London Bridge: Not as grand or memorable as it’s British counter part with the same name, this bridge is actually from England. It used to span the River Thames in London!
• Quirky Roadside Attractions: From the Cadillac Ranch in Texa to Tinkertown in New Mexico to the Blue Whale of Catoosa in Oklahoma, Route 66 overflows with charm and eccentricity. 

Why You’ll Love It: Route 66 is a celebration of Americana, offering time-travel vibes through diners, motels, and roadside oddities while showcasing the beauty of the American Southwest. 

3. Blue Ridge Parkway – North Carolina & Virginia 

Winding through the Appalachian Mountains, the Blue Ridge Parkway is known as “America’s Favorite Drive.” This route is a haven for nature lovers and those seeking tranquility. 

Start the drive in Cherokee, North Carolina and drive North. If you can time it right, do this drive during the fall, when the leaves change colors. The riot of colors combined with a bounty of scenic overlooks will have you frequently stopping to take photos. End your trip in Afton, Virginia before perhaps driving East to visit Monticello – Thomas Jefferson’s home and property. 

Must-See Highlights: 

• Shenandoah National Park: Traverse trails that lead to cascading waterfalls and panoramic mountain views. 
• Biltmore: This iconic home and property was a dream-made-reality by George W. Vanderbilt. The French renaissance architecture has 250 rooms and hundreds of acres of land to explore. 
• Great Smoky Mountains National Park: Immerse yourself in one of the most biodiverse parks in the U.S., filled with lush forests and mist-covered peaks. 
• Scenic Overlooks: Stop at any of the dozens of pullovers for endless photo opportunities of the rolling blue-tinged mountains. 

Why You’ll Love It: The Blue Ridge Parkway offers a serene retreat into nature, with every mile providing peaceful beauty. GPS tends to be unreliable along the route. With a USA eSIM, you’ll be able to stay connected to your navigational tools as you drive. 

4. Florida Keys Overseas Highway – Florida 

If your idea of a road trip involves turquoise waters and island vibes, the Overseas Highway is for you. Stretching 113 miles over bridges and islands, this route connects mainland Florida to the southernmost point of the U.S. 

Start your trip where the highway begins – at a T intersection between US 1 and SR A1A. End your trip in Key West, the furthest southern city in the U.S. (and even drive to the southern-most point in the U.S. at the very end of town). 

Must-See Highlights: 

• Stunning Ocean Views: Drive over the Seven-Mile Bridge, surrounded by endless ocean blue. 
• Key Largo: Known for its world-class snorkeling and diving spots, it’s a must for underwater adventurers. 
• Key West: Celebrate spectacular sunsets, enjoy laid-back island life, and explore historic landmarks like Ernest Hemingway’s house. 

Why You’ll Love It: This road trip feels like a tropical vacation on wheels, perfect for unwinding and enjoying the slower pace of island life. For those who love engineering and modern marvels, they’ll enjoy passing over the bridges that seem to float out of the ocean at times. 

5. Great River Road National Scenic Byway – From Minnesota to Louisiana 

Trace the mighty Mississippi River on the “Best Drive in America” that stretches across ten states, immersing you in rich historical and cultural experiences. Keep an eye out for the white signs with the pilot’s wheel logo on it, designating that you’re on the right route. 

Start your trip at Itasca State Park in Northern Minnesota. If it’s summer, consider stopping by one of the 10,000 lakes in the state to enjoy some fun in the sun! End your trip in New Orleans, snagging a beignet from Cafe du Monde or trying a daiquiri on Bourbon Street. 

Must-See Highlights: 

• Fort Snelling (Minnesota): Delve into history at this 19th-century military fort with sweeping views of the river. 
• Pikes Peak State Park (Iowa): Hike trails with stunning vistas of the Mississippi and its rugged bluffs. 
• New Orleans (Louisiana): End your adventure with the soulful music, flavorful cuisine, and vibrant nightlife of the Big Easy. 

Why You’ll Love It: The Great River Road mixes natural beauty with historic stops and thriving cultural hubs, offering a window into America’s soul. Discover much of America’s history as you drive along this all important river. And explore the best the Midwest has to offer in the process! 

Tips for Your Ultimate U.S. Road Trip 

• Plan Your Stops: While spontaneity is part of the fun, planning key stops along your route ensures you don’t miss must-see attractions. 
• Pack Wisely: Bring essentials like snacks, water, a first-aid kit, and a reliable GPS or map app. 
• Check Weather & Travel Seasons: Some routes, like the Blue Ridge Parkway, shine in fall, while others, like the Florida Keys, are best during winter or early spring. 
• Stay Flexible: Leave room for detours—you never know when a hidden gem might capture your attention! 

Make It Yours 

The beauty of a road trip lies in the freedom to explore at your own pace. These routes are flexible enough for laid-back explorers and eager adventurers alike. Whether you’re soaking in dramatic vistas, discovering quirky attractions, or indulging in local flavors, there’s something magical waiting for you on every mile. 

Are you ready to hit the road? Gas up, grab your playlist, and set out on these unforgettable journeys! Happy travels!

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